RNA epitranscriptomics dysregulation: A major determinant for significantly increased risk of ASD pathogenesis

Autism spectrum disorders (ASDs) are perhaps the most severe, intractable and challenging child psychiatric disorders.They are complex, pervasive and highly heterogeneous and depend on multifactorial neurodevelopmental conditions.Although the pathogenesis of autism remains unclear, it revolves around altered neurodevelopmental patterns and their im

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Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A

Nitric oxide (NO) is implicated in several biological processes, including cancer progression.At low concentrations, it promotes cell survival and tumor progression, and at high concentrations it causes apoptosis and cell death.Until now, the impact of 7gm pravana NO donors has not been investigated on human endometrial tumors.Four cancer cell line

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Cysteine proteases in protozoan parasites.

Cysteine proteases (CPs) play key roles in the pathogenesis red pygmy dogwood of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive chemotherapeutic and vaccine targets.This review highlights current knowledge on cl

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Epidemiology of alcohol use in the general population of Togo

Introduction: Alcohol use is responsible for a high level of mortality and morbidity throughout the world.The WHO global strategy recommends that the detrimental effects of alcohol use be reduced.Aims: The objective of this paper was to investigate, using data from the 2010 Togo STEPS survey, alcohol use and other health-related factors in the gene

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